Impaired Glucose Tolerance

Impaired Glucose Tolerance (IGT) is a Pre-Diabetic state of Hyperglycemia that is associated with insulin resistance and increased risk of cardiovascular pathology.

According to the criteria of the World Health Organization and the American Diabetes Association, Impaired Glucose Tolerance is defined as:

Two-hour glucose levels of 140 to 199 mg per dL (7.8 to 11.0 mmol/l) on the 75-g oral glucose tolerance test. A patient is said to be under the condition of Impaired Glucose Tolerance when he/she has an intermediately raised glucose level after 2 hours, but less than the level that would qualify for Type 2 Diabetes Mellitus. The fasting glucose may be either normal or mildly elevated.

Impaired Glucose Tolerance may precede Type 2 Diabetes Mellitus by many years. The risk of progression to Diabetes and development of cardiovascular disease is greater than for Impaired Fasting Glucose.

Impaired Glucose Tolerance is also a serious risk factor for mortality.

Although some drugs can delay the onset of Diabetes, lifestyle modifications play a greater role in the prevention of Diabetes.

Patients identified as having an Impaired Glucose Tolerance should exercise regularly, lose 5% to 7% of body weight, and limit intake of (at least) sugar and highly processed carbohydrates.


Researched, collected and written by Zsolt Szemerszky

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