Diabetes news Potential cures Type 2

Could this be the end of injections for diabetes patients? Scientists create a pain-free skin patch that stimulates the body’s own insulin production

skin patch
Scientists create a pain-free skin patch that stimulates the body's own insulin production / Photo: stock image via Daily Mail

Millions of people with diabetes could benefit from a device which spells an end to painful insulin injections and finger prick tests.

Scientists have developed an innovative, pain-free skin patch that is applied weekly to stimulate the body’s own insulin production and control blood sugar levels.

The biochemically formulated treatment does this by delivering a natural substance, which is extracted from brown algae and mixed with therapeutic agents, through dissolvable microneedles.

It is even designed to release the active ingredients fast when needed and to slow or stop when glucose levels stabilize.

The US researchers say its effectiveness as a treatment has been proven after tests on mice.

Diabetes rates have soared over the past couple of decades. The disease affects 371 million people worldwide, half of whom are undiagnosed, according to the International Diabetes Federation.

The condition is a major cause of blindness, kidney failure, heart attacks, stroke and lower limb amputation.

Dr Richard Leapman, scientific director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) in Maryland, US, said:

‘This experimental approach could be a way to take advantage of the fact that persons with type 2 diabetes can still produce some insulin.

‘A weekly microneedle patch application would also be less complicated and painful than routines that require frequent blood testing.’

How the patch works

Insulin is a hormone made by the pancreas that allows your body to use sugar (glucose) from carbohydrates in the food that you eat.

It is secreted to move glucose from the bloodstream into cells where the sugar can be converted to energy or stored.

However, In type 2 diabetes, the body’s ability to make or use insulin is progressively impaired.

Many patients require insulin therapy, usually by injection just under the skin, in amounts that are calculated according to individual’s deficit of the hormone in the blood. But insulin therapy is not managed well in half of all cases, the researchers note.

Its formula consists of two compounds – exendin-4 and glucose oxidase – which react with the blood chemistry to trigger insulin secretion.

Each is matched with a phosphate mineral particle, which stabilizes the compound until it is needed.

Exendin-4 is similar in genetic makeup to a molecule the body naturally produces and secretes in the intestine in response to eating food.

This substance does not degrade in the bloodstream for an hour or more, so can have long-lasting effect after being released.

Indeed the patch can meet the body’s need for days instead of being used up all at once.

Smart-release technology

Rising glucose levels trigger the release of exendin-4; but exendin-4 then gets insulin flowing to reduce the glucose level, which slows down and stops the release of exendin-4.

‘That’s why we call it responsive, or smart, release,’ said senior investigator Dr Xiaoyuan Chen.

‘Most current approaches involve constant release. Our approach creates a wave of fast release when needed and then slows or even stops the release when the glucose level is stable.’

The researchers found about half an inch square contained enough of the drug to control blood sugar levels in mice for a week. Further research is needed to determine the correct patch size for humans.

A previous early human studies with microneedle patch devices that contain insulin have been carried out that are aimed to treat people with type 1 diabetes – when the body produces no insulin – as well as type 2.

The researchers are competing in crowded market of drug research and developers with similar ideas to provide a long-term treatment for diabetics.

‘Diabetes is a very serious disease and affects a lot of people,’ Dr Chen said. ‘Everybody is looking for a long-acting formula.’

Originally published by Claudia Tanner at Mail Online


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